Nathan, there's a lot of stuff here, but check out two entries from Phil:
ODBC Connection Not Working After Upgrade
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1. Create a 32 bit ODBC DSN connection to the database (ODBCAD32.exe).
2. Open DocuWare Administration and register the connection (under database connections).
3. Create a 64 bit ODBC connection with EXACTLY the SAME name as the 32 bit ODBC connection (ODBC Data Sources 64 bit).
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All you need to do is to create a 64 bit ODBC connection with exactly the same name as the original 32 bit ODBC connection. DocuWare Platform will then select the 64 bit ODBC driver.